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Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function

T Hu1, C Y Kao, R T Hudson

  • 1The Molecular and Cell Biology Department, The University of Texas at Dallas, Richardson, Texas 75083-0688, USA.

Molecular Biology of the Cell
|April 10, 1999
PubMed
Summary

1,3-cyclohexanebis(methylamine) (CBM) inhibits coatomer binding to Golgi membranes, impacting cellular secretion. However, Golgi integrity and ER-to-Golgi transport remain intact, suggesting COPI is not essential for these processes.

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