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Updated: Oct 23, 2026

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo
Published on: December 5, 2012
Force-current relationships in intraneural stimulation: role of extraneural medium and motor fibre clustering
T A Frieswijk1, J P Smit, W L Rutten
1Department of Electrical Engineering, University of Twente, Enschede, The Netherlands.
Abstract:
Animal experiments and model simulations of monopolar, intrafascicular nerve stimulation are presented to study force-current relationships (recruitment curves). The conductivity of the extraneural medium is of prime importance to the resulting recruitment cures: an insulating extraneural medium generally leads to steeper curves with lower threshold currents than a well-conducting extraneural medium. Extensive statistical comparison of experimental and model results suggests the occurrence of clustering of alpha-motoneurons within the fascicle, manifesting itself mainly by an increased spread in threshold currents, as opposed to the situation where the fibres are distributed uniformly throughout the entire fascicle.
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