Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dermatofibrosarcoma protuberans harboring t(9;22)(q32;q12.2).

H Sonobe1, M Furihata, J Iwata

  • 1Department of Pathology, Kochi Medical School, Japan.

Cancer Genetics and Cytogenetics
|April 13, 1999
PubMed
Summary

Dermatofibrosarcoma protuberans (DFSP) typically shows ring chromosomes, but this study found a rare case with a balanced t(9;22) translocation. This finding expands the known chromosomal abnormalities in DFSP.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to Letter, "Autophagy Plays a Crucial Role in Ameloblast Differentiation".

Journal of dental research·2024
Same author

Autophagy Plays a Crucial Role in Ameloblast Differentiation.

Journal of dental research·2023
Same author

FaceBase: A Community-Driven Hub for Data-Intensive Research.

Journal of dental research·2022
Same author

Spatiotemporal MicroRNA-Gene Expression Network Related to Orofacial Clefts.

Journal of dental research·2022
Same author

Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice.

Translational psychiatry·2017
Same author

Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice.

Translational psychiatry·2017

Area of Science:

  • Oncology
  • Cytogenetics
  • Dermatopathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer.
  • Chromosomal abnormalities are common in DFSP, with ring chromosomes frequently reported.
  • Translocations are less common but have been documented in a subset of DFSP cases.

Observation:

  • A DFSP case in a 23-year-old woman was analyzed using G-band technique and fluorescence in situ hybridization (FISH).
  • The tumor exhibited a unique balanced translocation, t(9;22)(q32;q12.2), as its sole chromosomal anomaly.
  • This specific translocation was confirmed by dual-color FISH analysis.

Findings:

  • The identified t(9;22)(q32;q12.2) translocation is an atypical finding for DFSP.
  • Unlike typical DFSP cases, this tumor lacked the presence of ring chromosomes.

Related Experiment Videos

  • The cytogenetic findings highlight the heterogeneity of chromosomal aberrations in DFSP.

    • Implications:

    • This case expands the spectrum of known cytogenetic alterations in dermatofibrosarcoma protuberans.
    • The absence of ring chromosomes in this translocation-positive DFSP challenges previous assumptions of their specificity.
    • Further research into diverse chromosomal abnormalities may refine DFSP classification and understanding.