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A case of chronic neutrophilic leukemia with deletion (11)(q23)
C Terré1, I Garcia, J N Bastie
1Laboratoire de Cytogénétique, Hôpital André Mignot, Le Chesnay, France.
Cancer Genetics and Cytogenetics
|April 13, 1999
Abstract:
We report a case of chronic neutrophilic leukemia (CNL) in a 68-year-old man. Karyotype showed a clonal abnormality, never described before in CNL: 46,XY,del(11)(q23). Southern blot analysis of the MLL gene did not reveal any rearrangement, and reverse transcriptase polymerase chain reaction (RT-PCR) analysis did not show any fusion of BCR-ABL. Treatment with hydroxyurea and cytosine arabisonide was ineffective.