Role of NGF in axotomy-induced c-Jun expression in medial septal cholinergic neurons

The extent of neuronal regeneration after axotomy largely depends on the survival capacity of the injured cell. It has been shown for a long time that nerve fiber transection results in retrograde changes in the parent neuronal cell body, and that these changes may eventually lead to neuronal degeneration. At present, little is known about the sequence of events initiated in a nerve cell body by the transection of its axonal process. In this report, we will focus on an interaction of nerve growth factor (NGF) with the transcription factor c-Jun in intact and axotomized septohippocampal projection neurons.