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Related Experiment Videos

Brain regions involved in articulation.

R J Wise1, J Greene, C Büchel

  • 1Imperial College School of Medicine, MRC Cyclotron Unit, Hammersmith Hospital, London, UK. richard@wren.rpms.ac.uk

Lancet (London, England)
|April 13, 1999
PubMed
Summary
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The left anterior insula and lateral premotor cortex, not Broca's area, are crucial for speech articulation planning. This functional imaging study reveals key brain regions involved in the motor act of speech production.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Speech Production

Background:

  • Traditionally, Broca's area (left inferior frontal gyrus) was considered essential for speech motor control.
  • However, lesion studies suggest the left anterior insula plays a critical role in accurate articulation.
  • This study investigates the neural systems underlying speech production using functional neuroimaging.

Purpose of the Study:

  • To identify the specific brain regions involved in speech articulation.
  • To differentiate the roles of Broca's area and the anterior insula in speech production.
  • To explore neural activity during various speech-related tasks.

Main Methods:

  • Positron emission tomography (PET) with oxygen-15-labelled water was used in 12 healthy participants.

Related Experiment Videos

  • Cerebral activity was measured during word repetition, word listening, and anticipation tasks at varying rates.
  • Functional imaging data were analyzed using specialized software.

    • Main Results:

    • Word repetition activated the left anterior insula, lateral premotor cortex, and posterior pallidum, but not Broca's area.
    • The left anterior insula and lateral premotor cortex showed overlapping activity for both auditory perception and articulation.
    • Articulation influenced activity in the left dorsolateral temporal cortex, indicating attention shifts during speech.

    Conclusions:

    • Speech articulation planning involves the left anterior insula and lateral premotor cortex, challenging the primary role of Broca's area.
    • The left basal ganglia appear dominant in speech processing.
    • Motor output for speech involves both cerebral hemispheres, despite left-hemisphere dominance for planning.