Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hox genes in digit development and evolution.

J Zákány1, D Duboule

  • 1Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland.

Cell and Tissue Research
|April 13, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development.

BMC biology·2018
Same author

A molecular approach to the evolution of vertebrate paired appendages.

Trends in ecology & evolution·2011
Same author

18 Muscle and tendon pattern is altered independently of skeletal pattern in HoxD mutant limbs.

Journal of anatomy·2006
Same author

The mouse Hoxd13(spdh) mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes.

Developmental biology·2001
Same author

Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations.

Genes & development·2001
Same author

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice.

The Journal of cell biology·2001
Same journal

Correction to: Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Deletion of CEACAM1 does not affect retinal and choroidal morphology or transcriptome.

Cell and tissue research·2026
Same journal

Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.

Cell and tissue research·2026
Same journal

Gill ionocytes of the Lake Magadi tilapia (Oreochromis Alcolapia grahami), an extremophilic teleost native to a highly alkaline environment.

Cell and tissue research·2026
Same journal

Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Effects of gestational protein restriction on autophagy dynamics during odontogenesis.

Cell and tissue research·2026
See all related articles

Homeobox (Hox) genes control vertebrate limb skeletal development. Gene dosage and order within HoxA and HoxD complexes determine limb segment lengths, with specific genes regulating upper arm, lower arm, and digit formation.

Area of Science:

  • Developmental Biology
  • Genetics
  • Evolutionary Biology

Background:

  • Homeobox (Hox) genes are crucial for establishing the anterior-posterior axis in developing embryos.
  • Specific Hox gene complexes, HoxA and HoxD, are known to play roles in vertebrate limb development.

Purpose of the Study:

  • To elucidate the role of Hox gene complexes in the proliferation and patterning of skeletal progenitor cells in the vertebrate limb.
  • To understand how quantitative differences in Hox gene expression correlate with specific limb segment lengths.

Main Methods:

  • Analysis of gene expression patterns within HoxA and HoxD complexes.
  • Investigating the quantitative contribution of individual Hox gene products to limb development.
  • Studying the effects of reduced gene dosage on limb morphology.

Related Experiment Videos

Main Results:

  • Hox gene combinations dictate the lengths of the upper arm, lower arm, and digits.
  • A quantitative reduction in Hox gene dosage leads to truncations in the corresponding limb regions.
  • The physical gene order and sequential activation within Hox complexes ensure precise developmental timing and outgrowth.

Conclusions:

  • Hox gene dosage and spatial organization are critical for vertebrate limb skeletal patterning.
  • Variations in digit development across tetrapods may be linked to differential regulation of Hox genes.
  • Further molecular analysis will illuminate the genetic control of limb development, evolution, and associated pathologies.