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Related Experiment Videos

Thalamic relay site for cold perception in humans.

K D Davis1, R M Lozano, M Manduch

  • 1Department of Surgery, University of Toronto, Ontario, Canada.

Journal of Neurophysiology
|April 14, 1999
PubMed
Summary

Researchers identified the neural pathway for cold sensation. Microstimulation in the thalamus

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Area of Science:

  • Neuroscience
  • Sensory Physiology

Background:

  • Neural pathways for temperature sensation remain largely uncharacterized.
  • Previous research in monkeys suggests the ventromedial posterior nucleus (VMpo) in the thalamus may be involved in cold perception.

Purpose of the Study:

  • To investigate the neural pathways responsible for cold sensation.
  • To determine the role of the VMpo region in the human thalamus in mediating cold perception.

Main Methods:

  • Examined neuronal responses to thermal skin stimulation in awake patients.
  • Assessed perceptual effects of microstimulation within the VMpo region during functional stereotactic surgery.

Main Results:

  • Microstimulation in the VMpo region elicited specific cold sensations in patients.
  • Identified thalamic neurons in the VMpo that responded to innocuous skin cooling in corresponding body areas.

Conclusions:

  • Provided the first direct evidence for a specific neural pathway mediating cold sensation in humans.
  • Localized this pathway to the VMpo region of the human thalamus.

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