Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p75NTR: A study in contrasts.

P A Barker1

  • 1Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, Canada H3A 2B4. mdpb@musica.mcgill.ca

Cell Death and Differentiation
|April 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strong and recurring seasonality revealed within stream diatom assemblages.

Scientific reports·2019
Same author

Major agricultural changes required to mitigate phosphorus losses under climate change.

Nature communications·2017
Same author

Eiger-induced cell death relies on Rac1-dependent endocytosis.

Cell death & disease·2016
Same author

High frequency variability of environmental drivers determining benthic community dynamics in headwater streams.

Environmental science. Processes & impacts·2014
Same author

Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization.

Neuroscience·2010
Same author

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.

Cell death and differentiation·2008

The p75 neurotrophin receptor (p75NTR) has diverse roles in cell signaling, collaborating with trk receptors or acting alone. Its function in neurotrophin pathways is context-dependent, influencing cell survival and apoptosis.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Signaling

Background:

  • Neurotrophins are crucial for neuronal development and survival.
  • TrkA, TrkB, and TrkC receptors mediate canonical neurotrophin functions like survival and growth.
  • The specific physiological role of the p75 neurotrophin receptor (p75NTR) remains less understood.

Purpose of the Study:

  • To elucidate the complex physiological functions of p75NTR in neurotrophin signaling.
  • To investigate how p75NTR interacts with trk receptors and its autonomous signaling capabilities.
  • To explore the context-dependent nature of p75NTR's role in cellular responses.

Main Methods:

  • Analysis of existing literature and experimental data on p75NTR and trk receptor interactions.
  • Comparison of p75NTR function in cells co-expressing trk receptors versus trk-deficient cells.

Related Experiment Videos

  • Consideration of potential signaling mechanisms and pathways involved in p75NTR function.

    • Main Results:

    • p75NTR exhibits low-affinity binding to all neurotrophins, unlike the selective trk receptors.
    • In cells co-expressing trk receptors, p75NTR modulates trk activity, enhancing responses or facilitating apoptosis.
    • In trk-deficient cells, p75NTR can independently activate signaling cascades, potentially leading to apoptosis via distinct pathways.

    Conclusions:

    • p75NTR's function is highly dependent on the cellular context and co-expression with trk receptors.
    • p75NTR plays a multifaceted role in neurotrophin signaling, acting as both a modulator and an independent signaling unit.
    • Understanding p75NTR's unique signaling system is critical for comprehending neurotrophin physiology and its implications in various biological processes.