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Does the tuberous sclerosis complex include intracranial aneurysms? A case report with a review of the literature
A Beltramello1, G Puppini, A Bricolo
1Department of Radiology, University of Verona, Policlinico B.go Roma, Italy.
Background:
Tuberous sclerosis is a protean, genetically determined disease that may involve any organ or tissue and lead to a great number of symptoms and clinical features.
Objective:
Diagnosis can be very difficult in cases with incomplete manifestations (formes fruste) lacking the classic signs of the disease.
Materials And Methods:
We report a case fulfilling the diagnostic criteria for tuberous sclerosis (shagreen patches, hypomelanotic macules, renal cysts and angiomyolipomas, and "migration tracts" in the cerebral white matter) in association with a giant intracranial aneurysm, but lacking mental retardation, epilepsy and facial angiofibroma.
Results:
Fourteen other cases of tuberous sclerosis and intracranial aneurysms, all but one without any clear sign of polycystic kidney disease, were found in the literature.
Conclusion:
We suggest that vascular dysplasias in general and aneurysms (mainly intracranial) in particular can be added to the other non-primary diagnostic features for the clinical diagnosis of tuberous sclerosis.