Brain biopsy using high-field strength interventional magnetic resonance imaging

Area of Science:

• Neurosurgery
• Radiology
• Neuropathology

Background:

• Stereotactic techniques are standard for brain lesion sampling.
• Interventional magnetic resonance imaging (MRI) offers detailed visualization for neurosurgical procedures.

Purpose of the Study:

• To evaluate the safety and efficacy of interventional MRI for brain biopsies.
• To assess the diagnostic yield and complication rates of this novel approach.

Main Methods:

• 35 brain biopsies were performed using interventional MRI and MRI-compatible instruments.
• Interactive scanning confirmed needle placement; intraoperative pathology verified tissue diagnosis.
• Magnetic resonance spectroscopy was employed in six cases for targeted evaluation.

Main Results:

• Diagnostic tissue was obtained in all 35 biopsies, guiding therapeutic decisions.
• Histological diagnoses included various primary brain tumors, metastasis, and other lesions.
• No significant hemorrhage occurred; complications were rare and manageable (transient hemiparesis, scalp cellulitis).
• Magnetic resonance spectroscopy accurately differentiated tumor recurrence from radiation necrosis.

Conclusions:

• Interventional 1.5-T MRI is a safe and effective modality for brain lesion evaluation.
• Magnetic resonance spectroscopic targeting shows promise in improving the diagnostic yield of brain biopsies.