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Related Experiment Videos

Zinc sulfate supplementation improves thyroid function in hypozincemic Down children.

I Bucci1, G Napolitano, C Giuliani

  • 1Cattedra di Endocrinologia, Università G. D'Annunzio, Chieti, Italy.

Biological Trace Element Research
|April 14, 1999
PubMed
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Zinc supplementation improved thyroid function in children with Down syndrome and low zinc levels. Supplementing zinc sulfate in hypozincemic Down children is a beneficial therapeutic approach.

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Genetics

Background:

  • Hypothyroidism is a common endocrine issue in individuals with trisomy 21 (Down syndrome).
  • Low plasma zinc levels are frequently observed in Down syndrome patients, impacting immune and growth functions.
  • Zinc deficiency is linked to impaired immune response and growth rate.

Purpose of the Study:

  • To investigate the connection between zinc deficiency and subclinical hypothyroidism in Down syndrome.
  • To assess the effects of cyclic zinc sulfate supplementation on thyroid function in Down syndrome children.

Main Methods:

  • Observational study correlating age, zinc levels, triiodotironine (T3), and thyroid-stimulating hormone (TSH).
  • Cyclic supplementation with zinc sulfate in children with Down syndrome and low zinc levels.

Related Experiment Videos

  • Monitoring of thyroid function markers (TSH) before and after supplementation periods.

    • Main Results:

    • Inverse correlations found between age and T3, and between zinc and TSH.
    • Patients with low zinc levels exhibited higher TSH levels at baseline.
    • Six months of zinc supplementation led to improved thyroid function, with significantly reduced TSH levels in hypozincemic patients.
    • A similar trend of TSH reduction was observed during a second supplementation cycle.
    • Post-treatment TSH levels in supplemented hypozincemic subjects were comparable to normozincemic individuals.

    Conclusions:

    • Zinc deficiency plays a role in subclinical hypothyroidism in Down syndrome.
    • Dietary zinc supplementation is a simple and effective therapeutic strategy for hypozincemic children with Down syndrome.
    • Zinc supplementation can normalize thyroid function in Down syndrome patients with zinc deficiency.