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Longitudinal changes in radial bone density in older men.

T R Overton1, T K Basu

  • 1Department of Biomedical Engineering, University of Alberta, Edmonton, Canada.

European Journal of Clinical Nutrition
|April 14, 1999
PubMed
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Bone density in older men did not decline over 18 months, but was lower than in younger men. Age-related bone loss averages about 1% per year across adulthood.

Area of Science:

  • Gerontology
  • Bone Metabolism
  • Radiology

Background:

  • Bone density and biochemical status are crucial for aging populations.
  • Understanding age-related bone changes in men is essential for public health.
  • Previous studies have shown varying results on bone density changes in older adults.

Purpose of the Study:

  • To investigate changes in radial bone density and biochemical markers over 18 months in older men.
  • To compare bone density in older men with that of a younger male cohort.
  • To assess the relationship between bone density and various biochemical and hormonal factors.

Main Methods:

  • Thirty-six healthy men (aged 66-76 years) were studied over 18 months.
  • Trabecular (TBD), cortical (CBD), and integral (IBD) bone densities were measured using computed tomography (gammaCT).

Related Experiment Videos

  • Serum and urine samples were analyzed for calcium, phosphate, vitamin D, alkaline phosphatase, and parathyroid hormone levels.

    • Main Results:

    • Serum 25-hydroxyvitamin D significantly decreased over time in older men.
    • Trabecular bone density (TBD) showed a slight increase in older men.
    • While no significant age-related changes were observed within the older group, their bone density was significantly lower than that of younger men.

    Conclusions:

    • Radial bone density did not decrease longitudinally in healthy older men over 18 months.
    • Older men exhibited significantly lower bone density compared to younger men.
    • Regression analysis suggests an average age-related bone loss of approximately 1% per year across adulthood (ages 29-76).