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Synthesis of glucuronides of multidrug resistance reversing drug MS-209
T Suzuki1, K Mabuchi, N Fukazawa
1Life Sciences Laboratory, Performance Materials R&D Center, Mitsui Chemicals, Inc., Mobara, Chiba, Japan.
Bioorganic & Medicinal Chemistry Letters
|April 14, 1999
Abstract:
We synthesized the glucuronides of MS-209 to identify the two main unknown metabolites in human urine. Reaction of MS-209 and glucuronyl trichloroacetimidate gave two beta-isomers, which were each glucuronate of (R)- and (S)-MS-209. These spectrum data were identical with the metabolites.