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First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy-beta-phenylalanines
1Center for Biofunctional Molecules and Department of Chemistry, Pohang University of Science and Technology, Korea.
Bioorganic & Medicinal Chemistry Letters
|April 14, 1999
Abstract:
A series of N-acyl-N-hydroxy-beta-Phe were designed, synthesized, and shown to have potent inhibitory activity for carboxypeptidase A (CPA). They are the first examples of CPA inhibitors having a hydroxamate functionality.