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Effects of 3alpha- and 3beta-galactosylated alpha-galactosylceramides on the immune system
T Sakai1, M Morita, N Matsunaga
1Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Bioorganic & Medicinal Chemistry Letters
|April 14, 1999
Abstract:
We compared effects of alpha-galactosylceramide (alpha-GalCer) and its 3alpha- or 3beta-galactosylated derivatives on the proliferation of murine spleen cells. The 3alpha-galactosylated alpha-GalCer showed stronger proliferative response than the parental alpha-GalCer, but the 3beta-galactosylated alpha-GalCer possessed weaker activity than the alpha-GalCer. In addition, alpha-Gal-3-Cer did not show immunostimulatory activity.