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Antimalarial activity of 3-hydroxyalkyl-2-methylene-propionic acid derivatives
M K Kundu1, M K Kundu, N Sundar
1Department of Chemistry, Indian Institute of Technology, Powai, Bombay.
Bioorganic & Medicinal Chemistry Letters
|April 14, 1999
Abstract:
Several Baylis-Hillman adducts and their derivatives were synthesized and evaluated as targeted potential anti-malarials. The compounds 4, 7 and 9 were found to have highest potency against P. falciparum in vitro. The in vivo test result of compound 4 and 9 against P. berghei demonstrated activity at 80 mg/Kg dose level.