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Cell-dependent function of HIV-1 Vif for virus replication (Review)
1Department of Virology, The University of Tokushima School of Medicine, Tokushima 770-8503, Japan.
International Journal of Molecular Medicine
|April 15, 1999
Summary
The Vif protein of human immunodeficiency virus type 1 (HIV-1) is crucial for progeny virion infectivity. Virions lacking Vif are defective before or during reverse transcription.
Area of Science:
- Virology
- Molecular Biology
- HIV Research
Background:
- The Vif protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral infectivity.
- Vif functions late in the viral life cycle.
- Vif-deficient virions produced in non-permissive cells exhibit defects.
Purpose of the Study:
- To review the functional and structural analyses of Vif-deficient HIV-1 virions.
- To summarize new data on Vif-deficient virions.
Main Methods:
- Functional analysis of Vif-deficient virions.
- Structural analysis of Vif-deficient virions.
Main Results:
- Vif-deficient virions are defective in steps before or during reverse transcription.
- New data on the characteristics of these virions are presented.
Conclusions:
- Vif plays a critical role in ensuring the infectivity of progeny HIV-1 virions.
- Understanding Vif's function is key to developing antiviral strategies.