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Motor function in irritable bowel syndrome
1Mayo Clinic and Mayo Foundation, Rochester, USA.
Summary
Abnormal motor function, or dysmotility, plays a key role in irritable bowel syndrome (IBS). This review highlights evidence showing how altered gut motility contributes to IBS symptoms and pain.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Irritable bowel syndrome (IBS) is a common disorder characterized by gastrointestinal symptoms.
- Symptoms like diarrhea, constipation, and pain suggest underlying motor disturbances in the gut.
Purpose of the Study:
- To review the evidence supporting the role of abnormal motor function in IBS.
- To examine the relationship between gut motility, sensory function, and pain in IBS patients.
Main Methods:
- Review of clinical, physiological, and pharmacological studies on IBS.
- Analysis of studies investigating intestinal transit and rectal motor responses.
Main Results:
- Physiological studies indicate disturbed transit in the small bowel and colon, and abnormal rectal responses in IBS.
- Intestinal contractions are linked to pain, suggesting interaction between motor and sensory pathways.
- Pharmacological therapies targeting motility support the role of dysmotility in IBS.
Conclusions:
- Clinical, physiological, and pharmacological evidence strongly supports abnormal motility as a key factor in IBS.
- Novel therapies aim to modulate both sensory and motor functions in IBS management.