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DNA dynamics and endogeneous fields
M Satarić1, S Zdravković, J A Tuszyński
1Faculty of Technical Sciences, University of Novi Sad, Yugoslavia.
Bio Systems
|April 15, 1999
Summary
Living cells generate AC fields that influence DNA dynamics. These endogenous fields can transition broad DNA excitations into highly localized ones, impacting cellular processes.
Area of Science:
- Biophysics
- Quantum Biology
- Molecular Dynamics
Background:
- Endogenous AC fields generated by living cells are increasingly recognized as potential modulators of intracellular processes.
- DNA dynamics are fundamental to cellular functions, including replication, transcription, and repair.
Purpose of the Study:
- To investigate the impact of endogenous AC fields on DNA dynamics.
- To explore the transition of DNA excitations under the influence of these cellular fields.
Main Methods:
- Utilized a quantum nonlinear vibron-phonon interaction model.
- Employed a model for highly localized excitation.
- Applied Kubo's formalism for linear response calculations.
Main Results:
- Demonstrated that endogenous AC fields can induce a transition from broad solitonic DNA excitations to highly localized ones.
- Quantified the effect of AC fields on the nature of DNA excitation localization.
Conclusions:
- Endogenous AC fields play a significant role in shaping DNA dynamics at the molecular level.
- The localization of DNA excitations is sensitive to the cellular electromagnetic environment, with implications for gene expression and regulation.