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Total and functional hepatic blood flow decrease in parallel with ageing.

M Zoli1, D Magalotti, G Bianchi

  • 1Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, University of Bologna, Policlinico S. Orsola, Italy.

Age and Ageing
|April 15, 1999
PubMed
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Total hepatic blood flow (THF) and functional hepatic flow (FHF) significantly decrease with age, particularly after 75 years. This reduction occurs without increased intrahepatic shunting, indicating a natural aging process.

Area of Science:

  • Gerontology
  • Hepatology
  • Cardiovascular Physiology

Background:

  • Hepatic blood flow is crucial for liver function and drug metabolism.
  • Age-related changes in physiological parameters are well-documented, but hepatic blood flow dynamics require further investigation.

Purpose of the Study:

  • To investigate the impact of aging on hepatic blood flow.
  • To quantify changes in total hepatic flow (THF) and functional hepatic flow (FHF) across different age groups.

Main Methods:

  • Non-invasive assessment of THF and FHF in 40 healthy subjects across four age brackets (<45, 45-60, 61-75, >75 years).
  • THF measured via pulsed echo-Doppler (portal and hepatic artery flow).
  • FHF determined by D-sorbitol hepatic clearance.

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Main Results:

  • Significant age-related decline observed in both THF and FHF (P<0.001).
  • The most pronounced reduction in THF and FHF occurred in individuals over 75 years.
  • THF and FHF showed a strong positive correlation (r=0.871, P<0.001) and both negatively correlated with age.

Conclusions:

  • Aging is associated with a substantial reduction in hepatic blood flow.
  • No evidence of increased intrahepatic shunting was found, suggesting a direct age-related decrease in flow.