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No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease
F Wavrant-DeVrièze1, V Rudrasingham, J C Lambert
1Mayo Clinic Jacksonville, FL 32084, USA.
Neuroscience Letters
|April 15, 1999
Abstract:
Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.