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Related Experiment Videos

Progressive catatonia.

J R Brasić1, D Zagzag, S Kowalik

  • 1Department of Psychiatry, Bellevue Hospital Center, New York University School of Medicine, NY 10016-6481, USA. brasij01@popmail.med.nyu.edu

Psychological Reports
|April 16, 1999
PubMed
Summary
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This case study details a young man with pervasive developmental disorder experiencing progressive neurological decline, including catatonia and hemiparesis. Findings suggest a potential inherited neurodegenerative disorder, highlighting the importance of assessing catatonia in such cases.

Area of Science:

  • Neurology
  • Neuroscience
  • Genetics

Background:

  • Presents a rare case of progressive neurological deterioration in a young adult with childhood-onset pervasive developmental disorder.
  • Highlights the complex interplay between neurodevelopmental disorders and subsequent neurodegeneration.

Observation:

  • The patient exhibited persistent catatonia, right hemiparesis, and oral-facialbuccal dyskinesia.
  • Quantitative electroencephalography showed decreased amplitude, consistent with catatonia.
  • Nerve and muscle biopsies revealed large axon degeneration and myopathic changes.

Findings:

  • Positron emission tomography indicated hypometabolism in the right cerebral and cerebellar hemispheres.
  • Despite electroconvulsive treatments, the patient's neurological condition continued to deteriorate.

Related Experiment Videos

  • The clinical presentation suggests a possible inherited neurodegenerative disorder.

    • Implications:

    • Emphasizes that catatonia can be a treatable symptom associated with various neurological conditions.
    • Stresses the importance of evaluating for catatonia in patients with progressive brain degeneration.
    • Contributes to understanding a severe variant of progressive brain degeneration.