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Microfabricated filters for microfluidic analytical systems.

B He1, L Tan, F Regnier

  • 1Department of Chemistry, Purdue University, Lafayette, Indiana 47907, USA.

Analytical Chemistry
|April 16, 1999
PubMed
Summary
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New microfluidic filters utilize electroosmotic flow (EOF) for effective particle removal. These lateral percolation filters efficiently separate dust and cells from solvents.

Area of Science:

  • Microfluidics
  • Materials Science
  • Analytical Chemistry

Background:

  • Microfabrication techniques are crucial for developing advanced analytical devices.
  • Controlling fluid flow and particle separation at the microscale presents significant challenges.
  • Electroosmotic flow (EOF) offers a promising method for manipulating fluids in microchannels.

Purpose of the Study:

  • To develop and characterize novel lateral percolation filters for microfluidic systems.
  • To investigate the use of EOF for driving fluid flow through these filters.
  • To demonstrate the filters' efficacy in removing particulate matter from solvents.

Main Methods:

  • Micromachining quartz wafers using deep reactive ion etching to create microchannel networks.

Related Experiment Videos

  • Utilizing EOF by applying lateral voltage to silanol groups on channel walls.
  • Modifying channel surfaces with polyacrylamide coatings to control protein adsorption.
  • Testing filter performance with various particulate materials, including cells.

    • Main Results:

    • Successfully fabricated microchannel networks acting as lateral percolation filters.
    • Demonstrated EOF-driven flow through the filters.
    • Achieved controlled adsorption of cationic proteins via surface modification.
    • Validated filter efficacy in removing diverse particulate contaminants.

    Conclusions:

    • Lateral percolation filters micromachined in quartz are effective for microscale fluid filtration.
    • EOF provides a viable mechanism for driving flow and enabling filtration.
    • Surface modification allows for tunable adsorptivity, enhancing filter versatility.
    • These filters show potential for applications in solvent purification and cell separation.