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Related Experiment Videos

[Lethal varicella in infants].

B Weigel, A Du Chesne, D Leopold

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |December 15, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Varicella (chickenpox) can be fatal in children, even when skin lesions are healing. Fatal outcomes were linked to varicella hepatitis and meningoencephalitis, not bacterial superinfections.

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    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Pathology

    Background:

    • Varicella (chickenpox) is generally considered a mild childhood illness.
    • Fatal complications of varicella are rare, with bacterial superinfections historically being a concern.
    • However, severe forms like varicella pneumonia, encephalitis, and hemorrhagic-gangrenous varicella can lead to mortality.

    Observation:

    • This report details two fatal cases of varicella in young children (1.5 and 2 years old).
    • Both children presented with healing skin lesions.
    • One child died suddenly at home, with post-mortem findings of perivenous encephalitis and varicella hepatitis.
    • The second child developed meningoencephalitis and abscess formation, leading to death shortly after hospital admission.

    Findings:

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    • Fatal outcomes were associated with viral complications rather than bacterial superinfections.
    • Histopathological examination revealed perivenous encephalitis and varicella hepatitis in one case.
    • The second case showed severe cerebral edema, cytolysis, and hemorrhages consistent with meningoencephalitis.

    Implications:

    • These cases highlight the potential for severe, fatal varicella complications even in seemingly recovering children.
    • Emphasizes the need for vigilance in diagnosing and managing severe varicella presentations in pediatric populations.
    • Suggests that viral-mediated complications, such as encephalitis and hepatitis, pose a significant risk for mortality in severe varicella cases.