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Potential uses for quality-of-life measures in childhood inflammatory bowel disease
1Erasmus University and Sophia Children's Hospital, Department of Child and Adolescent Psychiatry, Rotterdam, The Netherlands.
Insights
Children with inflammatory bowel disease experience reduced health-related quality of life (HRQOL) across multiple domains. More multicenter studies are crucial to understand the impact of Crohn's disease and ulcerative colitis on pediatric HRQOL.
Area of Science:
- Pediatric gastroenterology
- Quality of life research
- Chronic disease management
Background:
- Inflammatory bowel disease (IBD) significantly impacts children's physical, psychological, and social functioning.
- Existing research on health-related quality of life (HRQOL) in pediatric IBD is limited.
- There is a need for comprehensive studies on HRQOL in pediatric IBD.
Purpose of the Study:
- To highlight the reduced HRQOL in children with IBD.
- To emphasize the necessity of multicenter studies for pediatric IBD HRQOL research.
- To outline approaches for conducting quality of life studies in pediatric IBD.
Main Methods:
- Review of existing literature on HRQOL in pediatric IBD.
- Discussion of perspectives for conducting HRQOL studies.
- Identification of issues in designing multicenter clinical studies for pediatric IBD.
Main Results:
- Children with IBD exhibit diminished HRQOL in physical, psychological, and social domains.
- Multicenter studies are essential to assess the impact of IBD, its treatments, and complications on pediatric HRQOL.
- Various perspectives and considerations for HRQOL study design in pediatric IBD were discussed.
Conclusions:
- Pediatric IBD significantly impairs health-related quality of life.
- Multicenter research is vital to fully understand the effects of IBD on children's well-being and outcomes.
- Standardized approaches are needed for robust HRQOL assessment in pediatric IBD clinical studies.
Abstract:
Health-related quality of life (HRQOL) in children with inflammatory bowel disease is clearly reduced in the physical as well as in the psychological and social functioning domains. However, very few studies of these children have been performed from a quality-of-life perspective. Multicenter studies on HRQOL are needed to answer questions about the impact of Crohn's disease and ulcerative colitis and their treatment and complications on HRQOL in children and adolescents and their association with outcome. This article describes perspectives from which quality of life studies may be performed, potential uses of HRQOL measures, and issues that should be accounted for in designing multicenter clinical studies on this topic.