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Cyclopia associated with triploidy and hydatidiform mole: a case report
Teratology
|October 1, 1978
Summary
This case report details a rare cyclops fetus with a 69 XYY chromosomal abnormality and partial hydatidiform mole. The distinct entities of cyclopia and triploidy require further investigation for coincidental occurrence.
Area of Science:
- Medical Genetics
- Fetal Development
- Reproductive Medicine
Background:
- Cyclopia is a rare congenital anomaly characterized by the fusion of the orbits.
- Triploidy (69 chromosomes) is a severe chromosomal abnormality often associated with fetal demise.
- Partial hydatidiform mole involves abnormal placental growth.
Purpose of the Study:
- To report a unique case of a live-born cyclops fetus.
- To document the co-occurrence of cyclopia, 69 XYY triploidy, and partial hydatidiform mole.
- To discuss the distinct nature of cyclopia and triploidy.
Main Methods:
- Case report of a live 22-week-old fetus.
- Karyotyping to determine chromosomal pattern.
- Histopathological examination of placental tissue.
Main Results:
- The fetus presented with cyclopia.
- Karyotyping revealed a 69 XYY chromosome pattern (triploidy).
- The placenta showed features of a partial hydatidiform mole.
Conclusions:
- This case represents a unique combination of cyclopia, triploidy (69 XYY), and partial hydatidiform mole.
- Cyclopia and triploidy appear to be distinct entities despite some shared features.
- Further case reports are needed to determine if these conditions co-occur coincidentally.