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Increase in interleukin-6 and fibrinogen in peripheral blood after swine dust inhalation
B Sjörgren1, Z Wang, B M Larsson
1Department for Work and Health, Swedish National Institute for Working Life, Solna. Bengt.Sjogren@niwl.se
Objectives:
The inhalation of dust from swine confinement buildings causes inflammatory responses in the airways with a rise of interleukin-6 (IL-6). The purpose of this study was to confirm the increase in serum IL-6 after inhalation of swine dust and investigate a possible increase in plasma fibrinogen.
Methods:
Eight healthy nonsmoking volunteers inhaled dust for 4 hours inside a swine confinement building. Inhalable dust and endotoxin were sampled. The concentrations of IL-6 and fibrinogen were determined in serum and plasma.
Results:
The study showed a clear increase in the concentrations of IL-6 and fibrinogen after exposure.
Conclusions:
As fibrinogen is an important risk factor for ischemic heart disease, the increased concentration of fibrinogen among persons exposed to swine dust may increase the risk for this disease.