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Related Experiment Videos

Improved contrast agent bolus tracking using T1 FARM.

C A McKenzie1, R S Pereira, F S Prato

  • 1Lawson Research Institute, London, Ontario, Canada. cmckenz@lri.stjosephs.london.on.ca

Magnetic Resonance in Medicine
|April 16, 1999
PubMed
Summary

T1 Fast Acquisition Relaxation Mapping (T1 FARM) offers superior MRI contrast tracking over saturation recovery Turbo-FLASH (srTFL). T1 FARM provides linear measurements at higher concentrations, improving accuracy in dynamic contrast-enhanced MRI studies.

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Area of Science:

  • Medical Imaging
  • Radiology
  • Biomedical Engineering

Background:

  • Current MRI bolus tracking methods like saturation recovery Turbo-FLASH (srTFL) face signal saturation issues with high contrast agent concentrations.
  • This limitation hinders accurate quantification in dynamic contrast-enhanced MRI (DCE-MRI).

Purpose of the Study:

  • To compare the performance of T1 Fast Acquisition Relaxation Mapping (T1 FARM) against srTFL for MRI bolus tracking.
  • To evaluate the linearity and saturation characteristics of both techniques across varying contrast agent concentrations.

Main Methods:

  • Phantom studies were conducted to assess linearity with Gadolinium diethylenetriaminepentaacetic acid ([Gd-DTPA]) concentrations.
  • Canine left ventricle studies were performed to evaluate blood and tissue concentration curves derived from T1 FARM and srTFL.

Related Experiment Videos

  • Contrast-to-noise ratio (CNR) was analyzed for tissue concentration curves.

    • Main Results:

    • T1 FARM demonstrated linear measurements with [Gd-DTPA] up to 7.0 mmol/L in phantoms, whereas srTFL saturated above 2.0 mmol/L.
    • In canine left ventricles, T1 FARM blood concentration curves saturated with injections >0.075 mmol/kg, while srTFL saturated >0.025 mmol/kg.
    • T1 FARM enhanced CNR in tissue concentration curves by enabling measurements at higher, previously saturating, contrast concentrations.

    Conclusions:

    • T1 FARM is a more robust MRI bolus tracking technique than srTFL, particularly at higher contrast agent doses.
    • The improved linearity and reduced saturation of T1 FARM allow for more accurate quantification in DCE-MRI.
    • T1 FARM offers significant advantages for dynamic contrast-enhanced imaging requiring higher contrast concentrations.