Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural skin capillary rarefaction in essential hypertension.

T F Antonios1, D R Singer, N D Markandu

  • 1Blood Pressure and Dermatology Units, Department of Medicine, and the Clinical Pharmacology Unit, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK. t.antonios@sghms.ac.uk

Hypertension (Dallas, Tex. : 1979)
|April 16, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary counseling to reduce moderate sodium intake. Concerns about the methods, evidence and feasibility of lowering sodium intake.

EClinicalMedicine·2023
Same author

Dietary Sodium 'Controversy'-Issues and Potential Solutions.

Current nutrition reports·2021
Same author

Salt reduction in the United Kingdom: a successful experiment in public health.

Journal of human hypertension·2013
Same author

Plasma sodium and blood pressure in individuals on haemodialysis.

Journal of human hypertension·2012
Same author

Interested in developing a national programme to reduce dietary salt?

Journal of human hypertension·2011
Same author

Original articles: increased platelet volume in patients with adult polycystic kidney disease.

Platelets·2010
Same journal

Brain Iron in Nucleus Accumbens and Cognitive Function in Preeclampsia.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Hypertension Treatment Intentions: A Health Belief Model Analysis.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Changes in Retinal Microvasculature During Healthy Pregnancy Measured by AO.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Longitudinal Maternal IgG and IgA Glycosylation Profiles in Pregnancy Reveal Early Immune Alterations in Placenta-Related Complications: The Rotterdam Periconception Cohort.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Blood Pressure Variability and Outcomes Across Antihypertensive Regimens.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Rural Health and Health Disparities in Hypertension Management: A Scientific Statement From the American Heart Association.

Hypertension (Dallas, Tex. : 1979)·2026
See all related articles

Essential hypertension patients show reduced capillary density in finger skin. This reduction is primarily due to structural capillary loss, not just reduced blood flow, suggesting anatomical changes in hypertension.

Area of Science:

  • Cardiovascular research
  • Microcirculation physiology

Background:

  • Essential hypertension is linked to reduced capillary density (rarefaction) in tissues, potentially increasing peripheral resistance.
  • The underlying mechanisms of this capillary rarefaction in hypertension remain unclear.

Purpose of the Study:

  • To differentiate between structural and functional capillary rarefaction in the finger skin of patients with essential hypertension.

Main Methods:

  • Intravital video microscopy was used to examine finger skin microcirculation in 17 hypertensive patients and 17 controls.
  • Capillary density was measured before and after venous congestion to assess perfused versus total capillaries.

Main Results:

  • Hypertensive subjects had significantly lower baseline capillary density compared to normotensive controls.

Related Experiment Videos

  • While venous congestion increased capillary density in both groups, maximal density remained lower in hypertensive individuals.
  • Findings suggest structural capillary absence, not functional nonperfusion, is the main cause of reduced density.

    • Conclusions:

    • The study indicates that structural capillary loss is a significant factor in reduced skin capillary density in essential hypertension.
    • This structural rarefaction may contribute to increased peripheral resistance in hypertensive individuals.