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Accelerated splanchnic amino acid uptake after cardiac surgery
R Suojaranta-Ylinen1, M Pöyhönen, J Takala
1Critical Care Research Program, Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland.
Clinical Nutrition (Edinburgh, Scotland)
|April 17, 1999
Summary
Post-cardiac surgery, the splanchnic region significantly increases amino acid uptake and oxygen consumption, contributing to hypermetabolism. Peripheral tissues do not show similar metabolic changes.
Area of Science:
- Cardiology
- Metabolic Research
- Surgical Recovery
Background:
- Increased energy expenditure is common after cardiac surgery.
- Peripheral tissue metabolism changes do not fully account for this postoperative hypermetabolism.
Purpose of the Study:
- To investigate the role of the splanchnic region in postoperative hypermetabolism following cardiac surgery.
- To assess amino acid exchange and oxygen uptake in the splanchnic bed.
Main Methods:
- Measured systemic and regional (splanchnic, leg) amino acid exchange and oxygen uptake in 22 coronary bypass grafting patients.
- Data collected postoperatively, 2 hours later, and after hemodynamic stabilization.
- Hemodynamics and femoral exchange were also monitored.
Main Results:
- Splanchnic uptake of glutamine and gluconeogenetic amino acids (alanine, serine, threonine) significantly increased.
- Splanchnic oxygen consumption rose, while splanchnic blood flow remained stable.
- No significant changes in femoral amino acid exchange were observed, despite increased leg oxygen consumption.
Conclusions:
- The splanchnic region is a major contributor to early postoperative hypermetabolism after cardiac surgery.
- Increased splanchnic amino acid and oxygen uptake indicates high metabolic activity in this region.
- Amino acid release originates from sources other than peripheral muscle during this phase.