Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antioxidant transport by the human placenta.

S Schenker1, Y Yang, A Perez

  • 1The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7878, USA.

Clinical Nutrition (Edinburgh, Scotland)
|April 17, 1999
PubMed
Summary

Melatonin rapidly crosses the placenta, while S-adenosyl methionine (SAM) and vitamin E transfer slowly. The natural RRR form of vitamin E is transported best across the term human placenta.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The vacuum chest wall lifter in the treatment of pectus excavatum].

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica·2006
Same author

[Prevalence and consumption of medication in diabetes mellitus in Madrid (1996-2002)].

Revista clinica espanola·2006
Same author

Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial.

British journal of anaesthesia·2006
Same author

Addition of pioglitazone to stable insulin therapy in patients with poorly controlled type 2 diabetes: results of a double-blind, multicentre, randomized study.

Diabetes, obesity & metabolism·2006
Same author

[Advantages and characteristics of the laparoscopic approach in the elderly].

Cirugia espanola·2006
Same author

Pioglitazone and reductions in post-challenge glucose levels in patients with type 2 diabetes.

Diabetes, obesity & metabolism·2005

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Biochemistry

Background:

  • Maternal-fetal transfer of essential nutrients and antioxidants is crucial for fetal development.
  • Understanding placental transport mechanisms of key compounds like melatonin, SAM, and vitamin E is vital for prenatal health.
  • Limited data exists on the differential placental transfer rates of these specific antioxidants.

Purpose of the Study:

  • To quantify and compare the placental transfer rates of melatonin, S-adenosyl methionine (SAM), and various forms of vitamin E.
  • To investigate potential biotransformation or breakdown of these substances during placental transfer.
  • To determine if specific forms of vitamin E (natural RRR vs. acetate) exhibit differential transport.

Main Methods:

  • Utilized a single, isolated human placental cotyledon system in vitro.

Related Experiment Videos

  • Assessed transport rates by comparing the transfer of melatonin, SAM, and vitamin E against known markers like antipyrine and L-glucose.
  • Analyzed for biotransformation products of SAM and vitamin E.

    • Main Results:

    • Melatonin demonstrated rapid placental transfer, similar to the freely diffusible marker antipyrine, with no observed biotransformation.
    • S-adenosyl methionine (SAM) exhibited slow transfer, comparable to passively transported L-glucose, and underwent nonenzymatic breakdown into derivatives.
    • Vitamin E transfer was slow, approximately 10% of L-glucose transfer rate, with the natural RRR form and free vitamin showing preferential transport over the acetate form.

    Conclusions:

    • Melatonin is efficiently transferred across the term human placenta.
    • Placental transfer of SAM is slow and involves breakdown, suggesting limited direct transfer of the intact molecule.
    • Vitamin E transfer is limited, with evidence suggesting preferential transport of the natural RRR form and free vitamin E, warranting further investigation.