Non-traditional plasticization of polymeric films

Area of Science:

• Polymer science
• Materials science
• Pharmaceutical technology

Background:

• Eudragit RS 30 D is a widely used polymer for controlled drug release.
• Understanding the impact of excipients on polymer properties is crucial for optimizing drug formulations.

Purpose of the Study:

• To investigate the influence of methylparaben, ibuprofen, chlorpheniramine maleate, and theophylline on Eudragit RS 30 D.
• To evaluate the effect of methylparaben and ibuprofen on drug release from Eudragit RS 30 D coated beads.

Main Methods:

• Thermal analysis (DSC)
• Tensile testing
• X-ray diffraction (XRD)
• Dissolution testing

Main Results:

• Methylparaben, ibuprofen, and chlorpheniramine maleate decreased the glass transition temperature of Eudragit RS 30 D.
• Theophylline did not affect the thermal properties.
• Increased methylparaben and ibuprofen levels reduced film tensile strength and Young's modulus, enhancing flexibility.
• Higher methylparaben and ibuprofen concentrations in the coating decreased ibuprofen release rate.

Conclusions:

• Methylparaben and ibuprofen significantly modify the thermal and mechanical properties of Eudragit RS 30 D.
• These modifications influence drug release kinetics, suggesting potential for controlled release applications.
• Theophylline does not impact Eudragit RS 30 D's thermal characteristics.