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Related Experiment Videos

Formation of ondansetron polymorphs.

J M Llácer1, V Gallardo, A Parera

  • 1Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain.

International Journal of Pharmaceutics
|April 17, 1999
PubMed
Summary

Polymorphs of ondansetron were identified using advanced analytical techniques. Specific conditions like heating and certain solvents, including ethanol and methanol, were found to induce these structural changes.

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Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry

Background:

  • Ondansetron is a critical antiemetic medication.
  • Understanding its solid-state forms (polymorphs) is essential for drug formulation and efficacy.
  • Polymorphism can significantly impact a drug's physical and chemical properties.

Purpose of the Study:

  • To investigate the potential for ondansetron polymorphism.
  • To identify specific conditions that lead to the formation of different ondansetron polymorphs.

Main Methods:

  • Differential scanning calorimetry (DSC) for thermal analysis.
  • Infrared spectrophotometry (IR) for structural identification.
  • Proton nuclear magnetic resonance (1H NMR) spectroscopy for detailed structural elucidation.
  • Systematic variation of temperature, heating duration, pH, pulverization, and solvents (ethanol, methanol).

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Main Results:

  • Ondansetron exhibits polymorphism under specific conditions.
  • Heating ondansetron to varying temperatures for different durations induced polymorph formation.
  • The use of ethanol and methanol as solvents also led to the generation of distinct ondansetron polymorphs.
  • Other tested conditions (pH, pulverization) did not appear to induce significant polymorphic changes.

Conclusions:

  • Ondansetron can exist in multiple crystalline forms (polymorphs).
  • Thermal stress (heating) and specific organic solvents (ethanol, methanol) are key factors influencing ondansetron's solid-state form.
  • These findings are crucial for controlling ondansetron's physical properties during manufacturing and formulation.