Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The psychological stress model using motor suppression].

H Kamei1, Y Noda, T Nabeshima

  • 1Department of Neuropsychopharmacology & Hospital Pharmacy, Nagoya University School of Medicine, Japan.

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|April 17, 1999
PubMed
Summary

Psychological stress causes motor suppression in mice, a model for affective disorders. Sigma receptor agonists, not typical anxiolytics, reduced this conditioned fear stress response.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Usefulness of APRI and FIB-4 for the Prediction of Liver Fibrosis After Liver Transplantation in Patients Infected with Hepatitis C Virus.

Transplantation proceedings·2018
Same author

Successful Blood Transfusion Management of a Living Donor Liver Transplant Recipient in the Presence of Anti-Jr<sup>a</sup>: A Case Report.

Transplantation proceedings·2017
Same author

Changes in Muscle Strength and Six-Minute Walk Distance Before and After Living Donor Liver Transplantation.

Transplantation proceedings·2016
Same author

Successful Living-Donor Liver Transplantation for Cholestatic Liver Failure Induced by Allopurinol: Case Report.

Transplantation proceedings·2015
Same author

Considerable Risk of Restenosis After Endoscopic Treatment for Hepaticojejunostomy Stricture After Living-Donor Liver Transplantation.

Transplantation proceedings·2015
Same author

Postoperative Psychiatric Complications in Living Liver Donors.

Transplantation proceedings·2015

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Psychopharmacology

Background:

  • Psychological stress is linked to anxiety and depression.
  • Existing research focuses on physiological stressors, with limited data on psychological stress behaviors.
  • Motor suppression is a known response to stressors like footshock in animal models.

Purpose of the Study:

  • To investigate behavioral changes in psychological stress using a conditioned fear stress (CFS) model.
  • To characterize motor suppression as a conditioned emotional response.
  • To evaluate the efficacy of sigma receptor agonists and standard anxiolytics/antidepressants in the CFS model.

Main Methods:

  • Inducing conditioned fear stress (CFS) in mice by re-exposure to a footshock environment.

Related Experiment Videos

  • Measuring motor suppression as a behavioral outcome.
  • Administering sigma receptor agonists ((+)-N-allylnormetazocine, dextromethorphan) and comparing their effects to anxiolytics (diazepam, chlordiazepoxide) and antidepressants (imipramine, fluoxetine).

    • Main Results:

    • Mice displayed significant motor suppression when placed in the CFS environment.
    • Sigma receptor agonists markedly attenuated the motor suppression.
    • Typical anxiolytics and antidepressants showed no significant effect on CFS-induced motor suppression.

    Conclusions:

    • The conditioned fear stress (CFS) model effectively demonstrates psychological stress-induced motor suppression.
    • This model may be valuable for studying the pathogenesis of affective disorders, especially treatment-resistant forms.
    • Sigma receptor agonists show potential as novel therapeutic agents for stress-related affective disorders.