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[Diagnosis and treatment of Rolandic epilepsy]
Insights
Rolandic epilepsy in children often shows microfocal symptoms. Low-dose valproic acid (depakin) effectively achieved remission of seizures in all observed pediatric patients.
Area of Science:
- Pediatric Neurology
- Epileptology
- Clinical Neurophysiology
Context:
- Rolandic epilepsy is a common childhood epilepsy syndrome.
- The study observed 43 pediatric patients aged 2-14 years.
- Comprehensive examinations included neurological, genealogical, neurophysiological, and neuroradiological assessments.
Purpose:
- To investigate the clinical characteristics, diagnostic findings, and treatment outcomes of Rolandic epilepsy in children.
- To evaluate the efficacy of low-dose valproic acid in achieving seizure remission.
- To explore potential correlations between neuroradiological findings, epileptic focus, and disease prognosis.
Summary:
- Microfocal symptomatology, including ptosis and infantile cerebral paralysis syndrome, was noted.
- Neuroradiological findings did not correlate with epileptic focus location or prognosis.
- Electroencephalographic abnormalities were present in clinically healthy relatives in 10 cases.
- All patients achieved remission of seizures with low-dose valproic acid (20 mg/kg daily).
Impact:
- Demonstrates the effectiveness of low-dose valproic acid in treating pediatric Rolandic epilepsy.
- Highlights the potential for subclinical EEG findings in relatives.
- Provides insights into the diagnostic and prognostic factors in this common childhood epilepsy.
Abstract:
Rolandic epilepsy belongs to the most frequent forms of epilepsy in children. 43 patients aged 2-14 years were observed. Complex neurologic, genealogic, neurophysiologic and neuroradiologic examinations was performed. There was a microfocal symptomatology in the form of ptosis and syndrome of infantile cerebral paralysis. The changes found at neuroradiologic examination were not related to the location of an epileptic focus and didn't influence the prognosis of the disease. In 10 cases electroencephalographic patterns were observed in clinically healthy relatives. In all the patients a remission of the fits was achieved. Administration of low doses (20 mg/kg daily) of valproic acid (depakin) resulted in a remission of the fits.