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Gastroesophageal reflux in children with cystic fibrosis
M Bosheva1, D Ivancheva, N Genkova
1Department of Paediatrics, Higher Medical Institute, Plovdiv, Bulgaria.
Insights
Gastroesophageal reflux (GER) is common in children with cystic fibrosis (CF), particularly during sleep. Cisapride treatment for GER in these patients was found to be safe and effective.
Area of Science:
- Pediatric Gastroenterology
- Pulmonology
- Gastrointestinal Motility Disorders
Background:
- Cystic Fibrosis (CF) affects multiple organs, including the gastrointestinal tract.
- Gastroesophageal reflux (GER) is a potential complication in children with CF.
- Understanding GER frequency and management is crucial for CF patient care.
Purpose of the Study:
- To determine the frequency of GER in pediatric CF patients.
- To evaluate the effectiveness and safety of GER management strategies in this population.
Main Methods:
- Twelve children diagnosed with Cystic Fibrosis (CF) were enrolled.
- 24-hour esophageal pH monitoring was performed during clinical remission of pulmonary symptoms.
- Patients diagnosed with GER received Cisapride treatment (10 mg post-dinner).
Main Results:
- GER was confirmed in 7 out of 12 children (58.3%), all over 6 years old.
- Reflux events occurred exclusively during sleep.
- No correlation was found between GER and the timing of inhalational therapies.
- Cisapride treatment demonstrated safety and efficacy in managing GER.
Conclusions:
- GER is a frequent condition in children with CF, especially in older children and during sleep.
- Cisapride is a safe and effective therapeutic option for managing GER in pediatric CF patients.
- Further research may explore the impact of GER on pulmonary status in CF.
Abstract:
The aim of the study is to reveal the frequency of gastroesophageal reflux /GER/ in children with cystic fibrosis /CF/ and the possibilities of GER's management. Twelve children with CF were monitored for GER by 24-hour pH monitoring of the distal part of the oesophagus, according to the instructions of ESPGAN with Digitrapper MK III, at the time of clinical remission of pulmonary involvement. All patients with diagnosed GER were treated with 10 mg. Cisapride an hour after dinner. GER was proven in 7 children older than 6 years, only while asleep and with no correlation with the time of inhalations. Treatment for GER was safe and effective.