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Related Experiment Videos

Parent-of-origin effect in panic disorder.

F Haghighi1, A J Fyer, M M Weissman

  • 1Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York, USA.

American Journal of Medical Genetics
|April 17, 1999
PubMed
Summary

This study investigated parent-of-origin effects in panic disorder (PD). Findings suggest potential, but not yet confirmed, differences in maternal versus paternal transmission risks for PD.

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Area of Science:

  • Genetics
  • Psychiatry
  • Behavioral Science

Background:

  • Panic disorder (PD) is a common psychiatric condition.
  • The role of parent-of-origin effects in PD heritability is not fully understood.
  • Investigating transmission patterns can elucidate genetic and environmental influences.

Purpose of the Study:

  • To examine parent-of-origin effects in panic disorder (PD).
  • To compare maternal versus paternal transmission of PD under different diagnostic models.
  • To analyze the impact of diagnostic criteria on observed transmission patterns.

Main Methods:

  • Analysis of 64 pedigrees with panic disorder.
  • Application of narrow (definite/probable PD) and broad (entire PD symptomatology) diagnostic models.

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  • Comparison of offspring risk and sex ratios from maternal versus paternal transmission.

    • Main Results:

    • No significant differences in offspring proportion from transmitting mothers vs. fathers overall.
    • Nominally significant sex ratio differences in pure pedigrees under the broad model (P < .05).
    • Nominally significant differences in cumulative lifetime PD risk between offspring of transmitting mothers and fathers (P < .0005 and P < .05).

    Conclusions:

    • Provisional evidence suggests potential parent-of-origin influences on panic disorder heritability.
    • Diagnostic model choice impacts the detection of transmission differences.
    • Further research is required to confirm these preliminary findings.