Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in thyroid function tests during short-term salsalate use.

R J McConnell1

  • 1The Thyroid Center, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Metabolism: Clinical and Experimental
|April 17, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Teaching posterior resin composites in UK and Ireland dental schools: do current teaching programmes match the expectation of clinical practice arrangements?

British dental journal·2018
Same author

Posterior composites: Update on cavities and filling techniques.

Journal of dentistry·2016
Same author

Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident.

British journal of cancer·2010
Same author

State-of-the-art techniques in operative dentistry: contemporary teaching of posterior composites in UK and Irish dental schools.

British dental journal·2010
Same author

Duties and training of dental nurses: how do Irish practices conform to European standards?

Community dental health·2008
Same author

Attitudes and use of rubber dam by Irish general dental practitioners.

International endodontic journal·2007
Same journal

Ablation of microglial estrogen receptor alpha predisposes male mice to diet-induced obesity.

Metabolism: clinical and experimental·2026
Same journal

Pathophysiology-based subtypes of individuals at high-risk of type 2 diabetes: multi-omics profiles and lifestyle differences across subtypes.

Metabolism: clinical and experimental·2026
Same journal

A thermosensitive TET-Parkin epigenetic axis couples mitochondrial quality control to adaptive thermogenesis in adipose tissue.

Metabolism: clinical and experimental·2026
Same journal

Raffinose targets the NQO1/NF-κB axis to attenuate DON-driven microglial activation and neuroinflammation via metabolic reprogramming.

Metabolism: clinical and experimental·2026
Same journal

Endothelial NPR-C promotes insulin resistance via Caveolin-1-mediated insulin transcytosis.

Metabolism: clinical and experimental·2026
Same journal

Macrophage-enriched GPR91 aggravates acute liver injury by inhibiting efferocytosis via the AC/cAMP/PPARγ pathway.

Metabolism: clinical and experimental·2026
See all related articles

Short-term salsalate use significantly lowers thyroid hormones (T4, T3, rT3) and suppresses TSH. Changes suggest reduced hormone binding to proteins is more influential than altered liver enzyme activity.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Salsalate's long-term effects on thyroid function are known, but short-term impacts remain unclear.
  • The mechanisms behind salsalate's effects on thyroid hormones (protein binding vs. liver enzyme activity) require further investigation.

Purpose of the Study:

  • To characterize thyroid function test changes during short-term salsalate administration.
  • To elucidate the mechanisms responsible for these observed thyroid function alterations.

Main Methods:

  • Eight subjects received a therapeutic dose of salsalate (1,500 mg twice daily).
  • Blood samples were collected at baseline, 24 hours, and 72 hours.
  • Assayed levels included total T4, total T3, reverse T3 (rT3), free T4 index (FTI), free T4 by direct equilibrium dialysis (FTD), and serum TSH.

Related Experiment Videos

Main Results:

  • Total T4, total T3, and rT3 levels significantly decreased by day 3 (to ~75% of baseline).
  • The T4/T3 ratio remained unchanged, while FTI declined but FTD was stable.
  • Serum TSH levels decreased significantly after 1 day and remained suppressed.

Conclusions:

  • Therapeutic salsalate doses induce significant reductions in total T4, T3, and rT3 without altering the T4/T3 ratio.
  • Despite stable free T4 levels, serum TSH remains suppressed.
  • The findings suggest that reduced thyroid hormone binding to serum proteins plays a more significant role than decreased hepatic 5'-monodeiodinase activity in mediating these effects.