Neurofibromatosis-Noonan syndrome and acute lymphoblastic leukemia: a report of two cases
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K J Klopfenstein1, A Sommer, F B Ruymann
1Division of Hematology/Oncology, Columbus Children's Hospital, Ohio 43205, USA.
Journal of Pediatric Hematology/Oncology
|April 17, 1999
Abstract:
Two boys with neurofibromatosis-Noonan syndrome in whom acute lymphoblastic leukemia (ALL) developed are described. Both patients demonstrated B-lineage leukemias with normal cytogenetics. They were treated with combination chemotherapy and remain in remission off therapy. Patients with neurofibromatosis-Noonan syndrome may be at increased risk for ALL.