Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Childhood medulloblastoma: progress and future challenges.

R J Packer1

  • 1Department of Neurology, Children's National Medical Centre, Washington, DC 20010, USA.

Brain & Development
|April 17, 1999
PubMed
Summary

Childhood medulloblastoma treatment is evolving, balancing efficacy with reduced long-term side effects. Research focuses on optimizing radiation and chemotherapy to improve outcomes and minimize neurocognitive sequelae in pediatric patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial.

AJNR. American journal of neuroradiology·2019
Same author

Treatment of pediatric cerebral radiation necrosis: a systematic review.

Journal of neuro-oncology·2016
Same author

Remarkable oxide ion conductivity observed at low temperatures in a complex superstructured oxide.

Advanced materials (Deerfield Beach, Fla.)·2010
Same author

CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis.

Neurology·2007
Same author

NF1 plexiform neurofibroma growth rate by volumetric MRI: relationship to age and body weight.

Neurology·2007
Same author

Treatment strategies for medulloblastoma and primitive neuroectodermal tumors.

Neurosurgical focus·2006

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Cancer Treatment Research

Background:

  • Medulloblastoma and primitive neuroectodermal tumors are leading pediatric malignancies.
  • Current treatments face challenges with long-term neurocognitive side effects and surgical complications like cerebellar mutism syndrome.

Purpose of the Study:

  • To review current management strategies for medulloblastoma in children.
  • To explore advancements in reducing treatment-related sequelae, particularly neurocognitive deficits.
  • To highlight the evolving role of chemotherapy and radiation therapy modifications.

Main Methods:

  • Review of recent treatment trials and studies on medulloblastoma management.
  • Analysis of approaches aimed at reducing craniospinal radiation therapy doses or delaying its use.

Related Experiment Videos

  • Evaluation of the expanding role and intensification of chemotherapy protocols.

    • Main Results:

    • Reduced-dose craniospinal radiation with adjuvant chemotherapy shows promising outcomes in older children.
    • Chemotherapy is increasingly integral for average-risk and poor-risk medulloblastoma.
    • Novel approaches are being investigated for infants and young children to improve outcomes and reduce sequelae.

    Conclusions:

    • Treatment strategies for medulloblastoma are adapting to minimize long-term neurocognitive deficits in children.
    • Optimized radiation and chemotherapy regimens are key to improving outcomes.
    • Further research is critical for improving the treatment of medulloblastoma in infants and young children.