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Ring constrained analogues of the orvinols: the furanomorphides
S M Husbands1, S W Breeden, K Grivas
1School of Chemistry, Cantock's Close, University of Bristol, England.
Bioorganic & Medicinal Chemistry Letters
|April 17, 1999
Abstract:
A series of furanomorphides were synthesised as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the mu opioid receptor compared to the orvinols.