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Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications
J S Plummer1, K A Berryman, C Cai
1Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA.
Bioorganic & Medicinal Chemistry Letters
|April 17, 1999
Abstract:
The synthesis and antithrombotic activity of a series of nonpeptide bicyclic thrombin inhibitors are described. We have explored the SAR around the P1' site. Modification of the P1' site has been found to affect potency and selectivity.