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Primary orbital Ewing sarcoma in a middle-aged woman
R Y Choi1, M J Lucarelli, P D Imesch
1Department of Ophthalmology and the Visual Sciences, University of Wisconsin, Madison 53705, USA. rychoi@facstaffwisc.edu
Orbital Ewing sarcoma, a rare cancer, was diagnosed in a 43-year-old woman using MIC-2 (CD99) stains. She remains tumor-free after radiotherapy and chemotherapy, marking a unique adult case.
Area of Science:
- Oncology
- Ophthalmology
- Pathology
Background:
- Ewing sarcoma is a rare bone and soft tissue cancer, typically affecting children and young adults.
- Orbital involvement is exceptionally uncommon, particularly in adults.
- Accurate diagnosis is crucial for effective treatment planning.
Observation:
- A 43-year-old woman presented with unilateral exophthalmos (protruding eye).
- Diagnostic imaging and specialized immunohistochemical stains, notably MIC-2 (CD99), confirmed primary orbital Ewing sarcoma.
- This represents an unusual late-adult presentation of the disease.
Findings:
- The patient received radiotherapy and multiagent chemotherapy.
- Post-treatment follow-up at 22 months showed no evidence of residual tumor.
- The patient achieved a tumor-free status.
Implications:
- This case highlights that orbital Ewing sarcoma can occur in adults beyond the fourth decade.
- It underscores the importance of immunohistochemistry, especially MIC-2 (CD99), in diagnosing rare orbital tumors.
- Successful treatment outcomes in adult orbital Ewing sarcoma warrant further investigation and reporting.
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