[Effect of local hypotensive therapy on ocular hemodynamics in patients with primary open-angle glaucoma]

Ocular hemodynamics is followed u p in patients with primary open-angle glaucoma after local application of 1% pilocarpine and 0.5% timolol maleate for 30 days. Forty-two patients (48 eyes) aged 47-82 years with initial, well-developed, and far-advanced condition were followed up. Diastolic, m ean dynamic pressure in the orbital artery, and perfusion pressure were measured. A significant decrease of diastolic pressure in the orbital artery, more expressed during the first ten days was observed in all patients. Later this value increased till the end of follow-up, but did not reach the initial level. Hence, patients with visual field loss are characterized by a higher local vascular tone and are less liable to its decrease after the above local hypotensive therapy.