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Biliary excretion and concentration of cefazolin
The American Journal of Gastroenterology
|December 1, 1976
Summary
Cefazolin achieves high concentrations in human bile, particularly in patients without biliary obstruction. This antibiotic demonstrates significant potential for treating biliary tract infections.
Area of Science:
- Pharmacology
- Biliary Tract Physiology
- Infectious Diseases
Background:
- Cefazolin is a widely used cephalosporin antibiotic.
- Understanding antibiotic penetration into the biliary tract is crucial for treating infections in this area.
Purpose of the Study:
- To investigate the excretion of cefazolin into the human biliary tract.
- To assess cefazolin levels in various biliary conditions and patient groups.
Main Methods:
- 34 patients were studied, including controls and those with cholelithiasis, cholecystitis, obstructive jaundice, or T-tube drainage.
- Two dosing regimens (single dose and multiple doses) were administered.
- Antibiotic activity in serum, bile, and gallbladder tissue was measured using the cylinder plate method.
Main Results:
- High cefazolin levels were observed in gallbladder bile in controls (127.0 mug/ml) and patients with visualized gallbladders (132.2 mug/ml) after multiple doses.
- Lower bile concentrations were found in cases of nonvisualized gallbladders or obstructive jaundice.
- Single-dose administration showed peak common duct bile levels of 10 mug/ml at 2 hours, decreasing to <1 mug/ml by 8 hours.
Conclusions:
- Cefazolin achieves significant concentrations in bile in the absence of obstruction.
- The findings suggest cefazolin's potential efficacy in treating biliary tract infections.