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Differences between relapsing-remitting and chronic progressive multiple sclerosis as determined with quantitative MR
Y Miki1, R I Grossman, J K Udupa
1Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA.
Purpose:
To investigate the cross-sectional relationships among multiple quantitative brain magnetic resonance (MR) imaging measurements in patients with relapsing-remitting versus chronic progressive multiple sclerosis (MS).
Materials And Methods:
Thirty-eight patients with MS (relapsing-remitting, 26, chronic progressive, 12) were examined. Lesion volume on T2-weighted MR images, contrast material-enhancing lesion volume, percentage of brain parenchymal volume (brain volume/[brain volume + cerebrospinal fluid volume), and magnetization transfer ratio histogram peak height for the whole brain were calculated.
Results:
Significant negative correlation was noted between volume on T2-weighted images and magnetization transfer ratio histogram peak height for both the relapsing-remitting and chronic progressive groups (P < .001 for both). A positive correlation was demonstrated for lesion volume on T2-weighted images and enhancing lesion volume in the relapsing-remitting group (P < .01) but not in the chronic progressive group. Negative correlations were demonstrated for enhancing lesion volume and magnetization transfer ratio histogram peak height (P = .02), for Expanded Disability Status Scale score and magnetization transfer histogram peak height (P = .02), and for Expanded Disability Status Scale score and percentage of brain parenchymal volume in the relapsing-remitting group (P = .004) but not in the chronic progressive group.
Conclusion:
The cross-sectional relationships among multiple quantitative brain MR imaging measurements are different between relapsing-remitting and chronic progressive MS.
Insights
Quantitative brain MRI measurements show different relationships in relapsing-remitting versus chronic progressive multiple sclerosis (MS). These findings highlight distinct disease progression patterns in MS subtypes.
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Multiple Sclerosis (MS) is a chronic neurological disease.
- Relapsing-remitting MS (RRMS) and chronic progressive MS (CPMS) represent distinct disease courses.
- Quantitative Magnetic Resonance Imaging (MRI) offers insights into brain changes in MS.
Purpose of the Study:
- To investigate cross-sectional relationships among quantitative brain MRI metrics.
- To compare these relationships between RRMS and CPMS patients.
Main Methods:
- Thirty-eight MS patients (26 RRMS, 12 CPMS) underwent MRI.
- Calculated metrics included T2 lesion volume, enhancing lesion volume, brain parenchymal volume fraction, and magnetization transfer ratio (MTR) histogram peak height.
- Analyzed cross-sectional correlations between these quantitative MRI measures.
Main Results:
- Significant negative correlation between T2 lesion volume and MTR histogram peak height in both RRMS and CPMS groups.
- Positive correlation between T2 lesion volume and enhancing lesion volume observed in RRMS, but not CPMS.
- Negative correlations found between enhancing lesion volume and MTR peak height, and between Expanded Disability Status Scale (EDSS) score and MTR peak height/brain parenchymal volume fraction in RRMS, but not CPMS.
Conclusions:
- The relationships among quantitative brain MRI measurements differ significantly between RRMS and CPMS.
- These distinct imaging-biomarker relationships may reflect different underlying pathological processes or disease progression mechanisms in MS subtypes.