A review of pharmacodynamics and pharmacokinetics in seizure management

Drug therapy is the most widely effective mode of treatment for epilepsy. Knowledge about the mechanisms of action and metabolism for antiepileptic medications has grown significantly in the past decade as understanding of neurotransmitters and cell physiology has evolved. This knowledge has resulted in engineering of new seizure controlling drugs. Understanding the pharmacological actions and pharmacokinetics of AEDs assists the advanced practice nurse in prescriptive decision-making and all nurses in monitoring patient response to therapy. This knowledge can also assist nurses to provide accurate information to patients receiving antiepileptic drugs.