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Related Experiment Videos

Ovarian function after bone marrow transplantation performed before menarche.

M Matsumoto1, O Shinohara, H Ishiguro

  • 1Department of Pediatrics, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa-ken 259-1193, Japan.

Archives of Disease in Childhood
|April 20, 1999
PubMed
Summary

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Bone marrow transplantation (BMT) in girls can preserve ovarian function, with most achieving menarche. Early BMT before puberty is linked to better outcomes, indicating long-term ovarian health benefits.

Area of Science:

  • Pediatric Oncology
  • Reproductive Endocrinology

Background:

  • Bone marrow transplantation (BMT) is a critical treatment for various childhood diseases.
  • The long-term effects of BMT, particularly on reproductive health, require thorough investigation.
  • Ovarian function is a key concern for female survivors of childhood cancer treated with BMT.

Purpose of the Study:

  • To evaluate the long-term impact of bone marrow transplantation (BMT) on the ovarian function of girls.
  • To determine the incidence of menarche and analyze follicle-stimulating hormone (FSH) levels in girls post-BMT.

Main Methods:

  • Study included 18 girls who underwent BMT before menarche, were disease-free for over six years, and were older than 14.
  • Investigated the occurrence of menarche and changes in basal serum FSH concentrations.

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  • Preparative regimen included irradiation and chemotherapy.

    • Main Results:

    • Twelve out of 18 patients achieved menarche, with a median age of 12.8 years.
    • Younger age at transplant (mean 7.2 years) correlated with achieving menarche.
    • FSH levels rose to menopausal concentrations after age 10, with variations observed in girls who achieved menarche.

    Conclusions:

    • High incidence of menarche suggests favorable long-term ovarian function in girls undergoing BMT at a young age.
    • Early BMT may preserve reproductive potential in female survivors.
    • Monitoring FSH levels provides insights into ovarian recovery post-BMT.