Developmental neurobiology: Alternative ends for a familiar story?

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Paul B. Baltes and colleagues described several key principles of development across the lifespan. The first four emphasize that development is continuous and complex. It is shaped by experience, interacting influences, changing abilities, and the relationship between biology and culture. Together, these principles show why development is more complex than a simple sequence of age-related changes.Development is LifelongDevelopment begins early and continues throughout life, with experiences at...

A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are themselves.

Paul B. Baltes and colleagues described several key principles of lifespan development to explain how individuals change from childhood through late adulthood. These principles focus on the allocation of personal resources, the capacity for change, and the influence of historical and cultural environments. They show that development can change but is also limited by individual and environmental conditions.Development Involves Changing Resource AllocationsAcross the lifespan, individuals...

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...